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Xx male syndrome, also known as de la chapelle syndrome or 46,xx testicular disorder of sex development (or 46,xx dsd) is a rare intersex condition in which an individual with a 46,xx karyotype develops a male phenotype

[2][3][4][5][6] in 90 percent of these individuals, the syndrome is caused by the father's y chromosome 's sry gene being atypically included in the crossing over of genetic. Sex chromosomes are the genetic elements that define a person's biological sex Learn about the xx and xy chromosomes, the sex determination system, and other chromosome combinations. A rare disorder where individuals with two x chromosomes develop male characteristics due to sry gene translocation.

Yes, men with xx male syndrome have two x chromosomes but exhibit male traits This condition arises when the sry gene translocates onto an x chromosome, triggering male development despite the absence of a y chromosome. Summary the 46, xx male syndrome is a rare sex chromosomal disorder in man [1] It mostly occurs due to unequal crossing over between x and y chromosomes during meiosis [2]

A 32 year old xx male with normal male phenotype and normal adrenarchal hair pattern, bilateral atrophic testes, normal phallus presented with azoospermia and infertility.

Several genetic mishaps conceive the 46,xx male genotype (rizvi 2008)

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